HitPredict

Interactor 1: PHF2 (O75151)
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)
Gene: PHF2

Interactor 2: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31753913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1096 Hs			1 801
+	Hs
		256411 PHF2_HUMAN (1-1096): 0: 919: 100.00		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		1067196 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		245098 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		164509 PHF8_HUMAN (1-1096): 0: 903: 47.35		TRI66_HUMAN (2-527): 1.93e-51: 197: 16.79
+	Hs
		1342841 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRD7_HUMAN (25-338): 4.42e-29: 125: 17.13
+	Hs
		1356828 PHF8_HUMAN (1-1096): 0: 903: 47.35		BRPF3_HUMAN (8-510): 5.66e-28: 123: 15.88
+	Hs
		600258 PHF8_HUMAN (1-1096): 0: 903: 47.35		TAF1_HUMAN (64-263): 1.16e-16: 87.2: 16.00
+	Hs
		245112 KDM2A_HUMAN (54-926): 0: 651: 19.24		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		999234 KDM2A_HUMAN (54-926): 0: 651: 19.24		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Sp
		293843 JHD1_SCHPO (91-899): 7.69e-172: 531: 19.40		BDF1_SCHPO (58-195): 3.54e-32: 134: 34.04
+	Sp
		293809 JHD1_SCHPO (91-899): 7.69e-172: 531: 19.40		YK82_SCHPO (27-186): 5.63e-31: 132: 29.88
+	Sp
		293841 JHD1_SCHPO (91-899): 7.69e-172: 531: 19.40		GCN5_SCHPO (289-454): 3.1e-31: 129: 22.29
+	Hs
		631425 MDC1_HUMAN (425-1089): 6.63e-30: 131: 12.88		BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00
+	Hs
		1056838 MDC1_HUMAN (425-1089): 6.63e-30: 131: 12.88		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		244438 MDC1_HUMAN (425-1089): 6.63e-30: 131: 12.88		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		244869 DIDO1_HUMAN (5-92): 3.08e-20: 99.7: 30.44		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		998710 MDC1_HUMAN (425-1089): 6.63e-30: 131: 12.88		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Hs
		999156 CXXC1_HUMAN (5-126): 2.47e-26: 117: 31.15		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Sc
		728742 SPP1_YEAST (4-133): 2.67e-28: 119: 21.33		BDF1_YEAST (16-240): 5.3e-20: 97.2: 22.47
+	Zm
		80272 B6TK34_MAIZE (5-59): 1.74e-25: 108: 30.91		K7TPV5_MAIZE (351-452): 2.06e-12: 72.4: 43.14