HitPredict

Interactor 1: PHAR2 (O75167)
Phosphatase and actin regulator 2
Gene: PHACTR2

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 33961781, 34079125, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~RPEL
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 634 Hs			1 375
+	Hs
		257143 PHAR2_HUMAN (1-634): 3.34e-66: 230: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		257126 PHAR2_HUMAN (1-634): 3.34e-66: 230: 100.00		POTEI_HUMAN (1-375): 0: 731: 91.20
+	Hs
		554315 MUC1_HUMAN (9-448): 1.75e-21: 101: 9.43		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		257139 PHAR2_HUMAN (1-634): 3.34e-66: 230: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		257140 PHAR2_HUMAN (1-634): 3.34e-66: 230: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		257136 PHAR2_HUMAN (1-634): 3.34e-66: 230: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		891891 PHAR4_HUMAN (3-634): 2.39e-45: 173: 33.10		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929922 PHAR4_HUMAN (3-634): 2.39e-45: 173: 33.10		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		932253 PHAR4_HUMAN (3-634): 2.39e-45: 173: 33.10		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Dm
		501561 Q9VZM9_DROME (6-634): 5.5e-39: 156: 24.47		ACT1_DROME (2-375): 0: 598: 98.13
+	Dm
		501562 Q9VZN2_DROME (99-634): 4.05e-37: 150: 23.83		ACT1_DROME (2-375): 0: 598: 98.13
+	Hs
		891978 PHAR3_HUMAN (203-634): 1.78e-33: 136: 34.02		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		892113 MACF1_HUMAN (456-631): 8.87e-32: 134: 17.26		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		3037 A0A0J9YVR0_HUMAN (2-183): 1.25e-34: 132: 38.22		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932331 PHAR3_HUMAN (203-634): 1.78e-33: 136: 34.02		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		554290 MUC1_HUMAN (9-448): 1.75e-21: 101: 9.43		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		932156 MDC1_HUMAN (16-565): 1.39e-17: 89.6: 10.23		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		933050 PHAR1_HUMAN (4-238): 2.33e-12: 71.9: 30.67		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		203220 SYNJ1_HUMAN (212-626): 6.72e-11: 67.7: 11.72		ACTC_HUMAN (2-375): 0: 592: 94.12