HitPredict

Interactor 1: CREST (O75177)
Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
Gene: SS18L1

Interactor 2: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 396 Hs			1 181
+	Hs
		257439 CREST_HUMAN (1-396): 3.15e-78: 248: 100.00		FOS_HUMAN (14-158): 2.36e-25: 102: 26.25
+	Mm
		562978 SSXT_MOUSE (1-396): 7.26e-71: 230: 56.22		ATF2_MOUSE (17-162): 1.01e-23: 98.4: 21.92
+	Hs
		345442 SSXT_HUMAN (1-396): 5.46e-68: 222: 53.83		FOS_HUMAN (14-158): 2.36e-25: 102: 26.25
+	Hs
		547804 SSXT_HUMAN (1-396): 5.46e-68: 222: 53.83		ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92
+	Hs
		402058 SSXT_HUMAN (1-396): 5.46e-68: 222: 53.83		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73
+	Hs
		60099 A4PIW0_HUMAN (1-342): 3.78e-54: 187: 47.65		ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92
+	Hs
		60094 A4PIV8_HUMAN (1-381): 2.63e-52: 182: 43.75		ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92
+	Mm
		345619 SMCA2_MOUSE (74-384): 6.58e-36: 142: 17.93		FOS_MOUSE (13-158): 2e-24: 99.5: 26.71
+	Mm
		404148 SMCA2_MOUSE (74-384): 6.58e-36: 142: 17.93		JUN_MOUSE (10-155): 1.94e-23: 96.5: 19.46
+	Hs
		345369 SMCA2_HUMAN (74-384): 1.05e-26: 114: 15.67		FOS_HUMAN (14-158): 2.36e-25: 102: 26.25
+	Hs
		401665 SMCA2_HUMAN (74-384): 1.05e-26: 114: 15.67		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73
+	Hs
		579181 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00
+	Hs
		345370 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		FOS_HUMAN (14-158): 2.36e-25: 102: 26.25
+	Hs
		566739 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		JUNB_HUMAN (27-155): 8.92e-26: 102: 18.46
+	Hs
		401666 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73
+	Hs
		401691 SC24C_HUMAN (134-389): 2.67e-09: 61.2: 15.97		JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73