HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30415952, 24951594
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 454
+	Hs
		257755 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69
+	Mm
		840196 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		MAD1_MOUSE (320-454): 2.16e-30: 119: 23.70
+	Mm
		840233 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		MXI1_MOUSE (321-450): 1.24e-29: 117: 27.69
+	Mm
		139907 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		MNT_MOUSE (244-452): 6.75e-25: 109: 20.83
+	Hs
		347665 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Rn
		61827 A6K9M6_RAT (30-167): 5.71e-15: 78.8: 25.00		MYC_RAT (1-454): 4.61e-115: 347: 88.57
+	Ce
		60879 SIN3_CAEEL (7-148): 3.88e-34: 145: 33.80		MXL3_CAEEL (367-439): 1.69e-20: 92.1: 32.88
+	Mm
		1141064 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61
+	Hs
		738990 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19
+	Dm
		1137188 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		X2JDM5_DROME (358-449): 1.1e-20: 97.1: 29.03
+	Mm
		840195 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		MAD1_MOUSE (320-454): 2.16e-30: 119: 23.70
+	Mm
		840232 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		MXI1_MOUSE (321-450): 1.24e-29: 117: 27.69
+	Hs
		840222 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69
+	Hs
		983439 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40
+	Mm
		139906 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		MNT_MOUSE (244-452): 6.75e-25: 109: 20.83
+	Mm
		1141057 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		Q91VN7_MOUSE (320-449): 4.17e-26: 107: 23.85
+	Hs
		1302431 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MNT_HUMAN (274-452): 2.36e-24: 107: 21.11
+	Hs
		1302436 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MAD3_HUMAN (320-450): 1.2e-25: 105: 26.72
+	Hs
		898177 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67