HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: ARI4A (P29374)
AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1)
Gene: ARID4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 11283269
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030336 - negative regulation of cell migration
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 1257
+	Hs
		257792 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		ARI4B_HUMAN (1-1257): 2.24e-180: 569: 40.35
+	Hs
		257744 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		KDM5A_HUMAN (219-580): 2.08e-61: 233: 14.33
+	Hs
		666503 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		ARI4A_HUMAN (1-1257): 0: 687: 100.00
+	Hs
		1117690 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		ARI4B_HUMAN (1-1257): 2.24e-180: 569: 40.35
+	Dm
		1137180 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q9VWP5_DROME (1-1165): 9.86e-120: 413: 20.03
+	Dm
		1137172 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		KDM5_DROME (205-637): 2.85e-62: 236: 11.54
+	Mm
		57769 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		ARI1A_MOUSE (234-957): 1.32e-66: 250: 8.51
+	Mm
		1141048 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		KDM5B_MOUSE (220-574): 2.33e-63: 239: 13.76
+	Dm
		51533 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		A1Z6M0_DROME (268-420): 1.84e-24: 113: 18.52