HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: PHF12 (Q96QT6)
PHD finger protein 12 (PHD factor 1) (Pf1)
Gene: PHF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26496610, 26841866, 24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PAH~PHF12_MRG_bd
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 1004
+	Mm
		1130953 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		PHF12_MOUSE (1-1004): 0: 1349: 95.92
+	Hs
		257773 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		BPTF_HUMAN (43-264): 2.26e-31: 135: 19.28
+	Hs
		257817 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		PF21A_HUMAN (1-241): 3.04e-30: 130: 16.21
+	Hs
		257809 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		CHD5_HUMAN (15-166): 1.47e-20: 100: 16.77
+	Hs
		257774 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96
+	Hs
		1300603 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		PHF12_HUMAN (1-1004): 0: 1360: 100.00
+	Sp
		143537 PST2_SCHPO (18-1106): 0: 770: 21.89		YAC5_SCHPO (25-106): 1.73e-22: 103: 32.93
+	Zm
		29277 A0A1D6MNA1_MAIZE (700-1076): 1.38e-100: 351: 19.58		A0A1D6JZC0_MAIZE (35-169): 8.95e-20: 97.5: 18.12
+	Ce
		60878 SIN3_CAEEL (7-148): 3.88e-34: 145: 33.80		Q18605_CAEEL (2-442): 9.67e-58: 219: 18.81
+	Dm
		1137187 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q9W410_DROME (791-964): 1.53e-70: 254: 34.98
+	Ce
		60807 SIN3_CAEEL (7-148): 3.88e-34: 145: 33.80		LE418_CAEEL (6-278): 1.56e-20: 100: 14.29
+	Sc
		609142 SIN3_YEAST (38-241): 6.57e-30: 131: 28.08		RCO1_YEAST (26-105): 1.4e-19: 96.4: 32.10
+	Hs
		1017340 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		BPTF_HUMAN (43-264): 2.26e-31: 135: 19.28
+	Hs
		1289744 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		PF21B_HUMAN (3-173): 8.73e-30: 127: 22.22
+	Hs
		1059812 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		CHD4_HUMAN (52-166): 3.04e-20: 99.6: 19.23
+	Mm
		1141048 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		KDM5B_MOUSE (23-112): 8.34e-20: 97.9: 29.03
+	Hs
		1018652 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		CHD3_HUMAN (11-166): 1.58e-19: 97.3: 16.96