HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: SP130 (Q9H0E3)
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)
Gene: SAP130

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26496610, 24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0030336 - negative regulation of cell migration
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 1048
+	Hs
		257782 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		257822 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		1302440 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Dm
		1137163 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q8IQI0_DROME (10-1044): 2.54e-36: 151: 14.73
+	Hs
		1056948 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		1300903 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76