HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: SDS3 (Q9H7L9)
Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)
Gene: SUDS3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	24981860, 26186194, 28514442, 11909966, 33961781
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030336 - negative regulation of cell migration
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 328
+	Hs
		257793 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		BRM1L_HUMAN (26-323): 4.07e-119: 347: 27.67
+	Mm
		1143589 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		SDS3_MOUSE (38-328): 4.23e-118: 345: 99.31
+	Hs
		257836 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		BRMS1_HUMAN (30-238): 1.52e-77: 239: 19.91
+	Hs
		1129647 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		BRM1L_HUMAN (26-323): 4.07e-119: 347: 27.67
+	Mm
		1141052 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		SDS3_MOUSE (38-328): 4.23e-118: 345: 99.31
+	Hs
		1302448 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		SDS3_HUMAN (21-328): 4.56e-117: 342: 100.00
+	Dm
		1137179 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q9VWG2_DROME (30-325): 4.37e-107: 317: 39.88
+	Dm
		1137182 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q9VYI2_DROME (26-242): 1.03e-72: 227: 23.04
+	Hs
		1302452 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		BRMS1_HUMAN (30-238): 1.52e-77: 239: 19.91