HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: HDAC9 (Q9UKV0)
Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
Gene: HDAC9

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12590135
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1162 Hs			1 1011
+	Mm
		1143586 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		HDAC4_MOUSE (1-1009): 0: 684: 53.86
+	Hs
		257779 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		HDAC1_HUMAN (623-1009): 3.2e-140: 430: 23.49
+	Hs
		257815 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		HDAC2_HUMAN (622-1009): 4.74e-130: 404: 22.67
+	Mm
		140278 SIN3B_MOUSE (25-1162): 0: 1348: 87.26		HDAC1_MOUSE (623-1009): 3.42e-140: 430: 23.49
+	Hs
		1302475 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		HDAC9_HUMAN (1-1011): 0: 799: 100.00
+	Hs
		880810 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		HDAC4_HUMAN (1-1009): 0: 691: 54.67
+	At
		186887 SNL1_ARATH (701-1102): 1.44e-95: 335: 20.49		HDA19_ARATH (630-1007): 1.5e-128: 400: 22.28
+	At
		186875 SNL3_ARATH (705-1090): 3.89e-89: 316: 16.58		HDA19_ARATH (630-1007): 1.5e-128: 400: 22.28
+	Hs
		1302480 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		HDAC5_HUMAN (1-1008): 0: 612: 55.67
+	Sc
		609122 SIN3_YEAST (38-241): 6.57e-30: 131: 28.08		HDA1_YEAST (623-1008): 4.76e-134: 422: 34.64
+	Ce
		60810 SIN3_CAEEL (7-148): 3.88e-34: 145: 33.80		G5ECH0_CAEEL (627-1006): 1.34e-128: 399: 23.20
+	Sc
		609058 SIN3_YEAST (38-241): 6.57e-30: 131: 28.08		RPD3_YEAST (619-1006): 1.04e-132: 409: 22.67
+	Dm
		1137165 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		HDAC1_DROME (625-1009): 4.99e-138: 426: 23.35
+	Dm
		184384 O17142_DROME (113-262): 1.22e-22: 107: 36.31		HDAC1_DROME (625-1009): 4.99e-138: 426: 23.35
+	Hs
		1038650 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		HDAC1_HUMAN (623-1009): 3.2e-140: 430: 23.49
+	Mm
		140270 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		HDAC1_MOUSE (623-1009): 3.42e-140: 430: 23.49
+	Hs
		1270395 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		HDAC2_HUMAN (622-1009): 4.74e-130: 404: 22.67
+	Mm
		936394 SIN3A_MOUSE (78-366): 2.73e-15: 83.4: 15.60		HDAC2_MOUSE (622-1009): 1.69e-129: 402: 22.67
+	Dm
		1137160 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q86NK9_DROME (630-1009): 7.27e-106: 358: 31.68
+	Ce
		60834 SIN3_CAEEL (7-148): 3.88e-34: 145: 33.80		HDA1_CAEEL (672-938): 6.36e-24: 108: 29.71