HitPredict

Interactor 1: DNJB6 (O75190)
DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)
Gene: DNAJB6

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 1255
+	Hs
		383929 DNJA3_HUMAN (3-326): 6.9e-83: 260: 24.85		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383639 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383889 DNJB8_HUMAN (1-231): 1.63e-84: 256: 59.31		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		243250 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383619 DNJB2_HUMAN (1-322): 1.43e-77: 241: 45.23		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		338830 DNJA3_HUMAN (3-326): 6.9e-83: 260: 24.85		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338003 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		243241 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		601821 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		238430 DNJA3_HUMAN (3-326): 6.9e-83: 260: 24.85		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Hs
		243261 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Mm
		1142038 DNJA3_MOUSE (3-326): 3.99e-84: 263: 24.71		MUSK_MOUSE (495-984): 5.85e-121: 398: 25.65
+	Hs
		411469 DNJA3_HUMAN (3-326): 6.9e-83: 260: 24.85		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		411313 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		243254 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		435729 DNJA3_HUMAN (3-326): 6.9e-83: 260: 24.85		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Hs
		435551 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Hs
		243262 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92