HitPredict

Interactor 1: DNJB6 (O75190)
DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)
Gene: DNAJB6

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 393
+	At
		1012789 Q0WN54_ARATH (3-326): 2.53e-87: 272: 22.83		MPK4_ARATH (71-393): 8.83e-127: 371: 18.98
+	Hs
		636259 DNJB1_HUMAN (3-325): 1.34e-87: 268: 26.19		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	At
		1012790 Q0WN54_ARATH (3-326): 2.53e-87: 272: 22.83		MPK5_ARATH (71-393): 2.03e-121: 357: 18.07
+	Hs
		636252 DNJB1_HUMAN (3-325): 1.34e-87: 268: 26.19		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	At
		1012791 Q0WN54_ARATH (3-326): 2.53e-87: 272: 22.83		MPK7_ARATH (67-383): 1.52e-119: 352: 18.71
+	Hs
		257931 DNJB6_HUMAN (1-326): 1.34e-84: 260: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		734993 DNJA3_HUMAN (3-326): 6.9e-83: 260: 24.85		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		243371 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		681350 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		257926 DNJB6_HUMAN (1-326): 1.34e-84: 260: 100.00		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		243318 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	At
		1012788 Q0WN54_ARATH (3-326): 2.53e-87: 272: 22.83		MPK2_ARATH (38-376): 2.46e-115: 342: 19.25
+	Hs
		681419 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		258230 DNJB6_HUMAN (1-326): 1.34e-84: 260: 100.00		STK26_HUMAN (65-367): 5.81e-103: 312: 31.80
+	Hs
		681423 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		243385 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		153086 DNJB1_HUMAN (3-325): 1.34e-87: 268: 26.19		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49
+	Hs
		681362 DNJA1_HUMAN (4-324): 1.03e-82: 257: 23.26		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Hs
		243329 DNJA2_HUMAN (5-325): 2.37e-80: 252: 19.31		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Hs
		682157 DJB13_HUMAN (3-116): 9.07e-25: 103: 50.44		AKT2_HUMAN (20-377): 7.89e-112: 337: 20.71