HitPredict

Interactor 1: DKC1 (O60832)
H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
Gene: DKC1

Interactor 2: GAR1 (Q9NY12)
H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)
Gene: GAR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

The method score is based on:

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781, 35271311, 24981860, 35575683, 19179534
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Gar1~TruB_C_2, Gar1~TruB_N
Common GO terms	GO:0001650 - fibrillar center GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005697 - telomerase holoenzyme complex GO:0007004 - telomere maintenance via telomerase and 5 others more... GO:0031429 - box H/ACA snoRNP complex GO:0034513 - box H/ACA snoRNA binding GO:0070034 - telomerase RNA binding GO:0072589 - box H/ACA scaRNP complex GO:0090661 - box H/ACA telomerase RNP complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	514
Hs

1	217

Service provided by Combinatics, Japan

Last updated: 11Aug2025