HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: DKK1 (O94907)
Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)
Gene: DKK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 266
+	Hs
		258359 LRP5_HUMAN (27-1615): 0: 1840: 100.00		DKK2_HUMAN (42-265): 7e-100: 293: 43.97
+	Hs
		258358 LRP5_HUMAN (27-1615): 0: 1840: 100.00		DKK4_HUMAN (85-265): 1.17e-79: 241: 41.94
+	Hs
		270245 LRP6_HUMAN (8-646): 0: 590: 37.98		DKK1_HUMAN (1-266): 3.3e-151: 424: 100.00
+	Mm
		222597 LRP6_MOUSE (8-646): 0: 590: 37.54		DKK1_MOUSE (1-266): 2.77e-137: 389: 81.25
+	Hs
		270344 LRP6_HUMAN (8-646): 0: 590: 37.98		DKK2_HUMAN (42-265): 7e-100: 293: 43.97
+	Hs
		957657 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		DKK2_HUMAN (42-265): 7e-100: 293: 43.97
+	Hs
		1269032 SORL_HUMAN (1357-1615): 2.37e-10: 68.2: 9.36		DKK2_HUMAN (42-265): 7e-100: 293: 43.97
+	Hs
		1349412 LRP1B_HUMAN (1254-1402): 6.09e-09: 63.5: 24.54		DKK2_HUMAN (42-265): 7e-100: 293: 43.97