HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: SOST (Q9BQB4)
Sclerostin
Gene: SOST

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	28514442, 33961781, 15908424, 21471202
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ldl_recept_b~Sclerostin
Common GO terms	GO:0045893 - positive regulation of DNA-templated transcription GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 213
+	Mm
		1265073 LRP5_MOUSE (27-1615): 0: 1829: 94.71		SOST_MOUSE (1-213): 8.98e-132: 370: 87.32
+	Hs
		270322 LRP6_HUMAN (8-646): 0: 590: 37.98		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Mm
		291932 LRP6_MOUSE (8-646): 0: 590: 37.54		SOST_MOUSE (1-213): 8.98e-132: 370: 87.32
+	Hs
		254290 LRP4_HUMAN (1358-1590): 1.14e-11: 72.4: 10.04		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Hs
		957637 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00
+	Hs
		1269017 SORL_HUMAN (1357-1615): 2.37e-10: 68.2: 9.36		SOST_HUMAN (1-213): 2.91e-135: 379: 100.00