HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: WN10A (Q9GZT5)
Protein Wnt-10a
Gene: WNT10A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 417
+	Hs
		135519 LRP5_HUMAN (27-1615): 0: 1840: 100.00		WN10B_HUMAN (37-417): 1.58e-153: 441: 61.68
+	Hs
		270279 LRP6_HUMAN (8-646): 0: 590: 37.98		WNT3_HUMAN (36-417): 1.46e-157: 450: 35.33
+	Hs
		270280 LRP6_HUMAN (8-646): 0: 590: 37.98		WNT3A_HUMAN (23-417): 2.18e-156: 446: 36.00
+	Hs
		135520 LRP6_HUMAN (8-646): 0: 590: 37.98		WN10B_HUMAN (37-417): 1.58e-153: 441: 61.68
+	Hs
		270272 LRP6_HUMAN (8-646): 0: 590: 37.98		WNT5A_HUMAN (22-417): 1.15e-149: 431: 34.07
+	Mm
		291927 LRP6_MOUSE (8-646): 0: 590: 37.54		WNT5A_MOUSE (22-417): 1.13e-148: 428: 33.82
+	Hs
		270252 LRP6_HUMAN (8-646): 0: 590: 37.98		WNT1_HUMAN (63-416): 2.65e-136: 396: 39.27
+	Mm
		291925 LRP6_MOUSE (8-646): 0: 590: 37.54		WNT1_MOUSE (63-416): 2.65e-136: 396: 39.27
+	Hs
		351100 LDLR_HUMAN (1182-1295): 3.76e-11: 70.1: 19.30		WN10A_HUMAN (1-417): 2.5e-177: 502: 100.00
+	Hs
		351059 LDLR_HUMAN (1182-1295): 3.76e-11: 70.1: 19.30		WNT3A_HUMAN (23-417): 2.18e-156: 446: 36.00
+	Hs
		135834 LDLR_HUMAN (1182-1295): 3.76e-11: 70.1: 19.30		WNT7A_HUMAN (50-417): 1.13e-144: 417: 36.96
+	Hs
		452001 SORL_HUMAN (1357-1615): 2.37e-10: 68.2: 9.36		WNT2_HUMAN (41-417): 2.78e-141: 409: 34.92
+	Dm
		54031 A1Z9D7_DROME (4-336): 1.86e-41: 169: 22.42		WNTG_DROME (316-416): 7.56e-38: 144: 42.57