HitPredict

Interactor 1: UBP12 (O75317)
Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12)
Gene: USP12

Interactor 2: DMWD (Q09019)
Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9)
Gene: DMWD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	19615732, 33844468, 21183687
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UCH~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 370 Hs			1 674
+	Hs
		905378 UBP46_HUMAN (5-370): 2.53e-133: 387: 88.53		DMWD_HUMAN (16-674): 7.39e-142: 431: 100.00
+	Hs
		259297 UBP12_HUMAN (1-370): 5.12e-139: 401: 100.00		WDR20_HUMAN (10-636): 5.31e-125: 384: 53.01
+	Hs
		905392 UBP46_HUMAN (5-370): 2.53e-133: 387: 88.53		WDR20_HUMAN (10-636): 5.31e-125: 384: 53.01
+	Hs
		103684 UBP2_HUMAN (17-367): 2.39e-102: 316: 25.68		G5E9A7_HUMAN (16-674): 2.7e-131: 403: 96.21
+	Ce
		90257 UBP46_CAEEL (16-370): 1.14e-111: 334: 58.17		WDR20_CAEEL (20-672): 1.46e-92: 305: 32.72
+	Sp
		1013881 UBP9_SCHPO (77-370): 2.85e-92: 289: 45.76		BUN62_SCHPO (155-485): 8.76e-86: 281: 28.07
+	Hs
		259300 UBP12_HUMAN (1-370): 5.12e-139: 401: 100.00		Q8WUW6_HUMAN (289-336): 2.84e-09: 61: 20.83
+	Hs
		197099 UBP36_HUMAN (15-368): 1.35e-98: 317: 24.65		PRP4_HUMAN (62-311): 1.14e-28: 122: 14.40
+	Hs
		1281441 UBP36_HUMAN (15-368): 1.35e-98: 317: 24.65		FBXW7_HUMAN (75-349): 3.2e-27: 119: 7.77
+	Hs
		271161 UBP2_HUMAN (17-367): 2.39e-102: 316: 25.68		FBXW7_HUMAN (75-349): 3.2e-27: 119: 7.77
+	Hs
		267805 UBP22_HUMAN (7-369): 7.91e-100: 306: 24.94		TAF5L_HUMAN (86-302): 2.46e-23: 106: 14.06
+	Hs
		64195 UBP27_HUMAN (7-369): 3.25e-100: 305: 23.28		TAF5L_HUMAN (86-302): 2.46e-23: 106: 14.06
+	Hs
		903571 UBP36_HUMAN (15-368): 1.35e-98: 317: 24.65		WDR5_HUMAN (402-646): 6.73e-18: 87.6: 7.97
+	Hs
		1346960 UBP36_HUMAN (15-368): 1.35e-98: 317: 24.65		NLE1_HUMAN (51-241): 2.96e-17: 87.2: 13.61
+	Hs
		267775 UBP51_HUMAN (34-369): 2.79e-94: 298: 24.80		TAF5L_HUMAN (86-302): 2.46e-23: 106: 14.06
+	Dm
		186227 Q9VDD8_DROME (11-367): 2.44e-96: 307: 23.32		GBLP_DROME (176-356): 1.88e-14: 76.9: 13.59
+	Sc
		742754 UBP13_YEAST (77-368): 2.48e-58: 203: 37.29		GBLP_YEAST (246-527): 9.07e-48: 172: 18.71