HitPredict

Interactor 1: LIPA2 (O75334)
Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)
Gene: PPFIA2

Interactor 2: PTPRD (P23468)
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)
Gene: PTPRD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	9624153
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SAM_1~Y_phosphatase
Common GO terms	GO:0042734 - presynaptic membrane GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 1912
+	Hs
		259643 LIPA2_HUMAN (1-1257): 1.83e-152: 493: 100.00		PTPRS_HUMAN (1-1912): 0: 1555: 71.33
+	Hs
		255236 LIPA3_HUMAN (1-1257): 1.49e-110: 377: 55.59		PTPRD_HUMAN (1-1912): 0: 1640: 100.00
+	Hs
		616970 LIPA1_HUMAN (1-1257): 6.82e-109: 372: 62.89		PTPRD_HUMAN (1-1912): 0: 1640: 100.00
+	Hs
		259635 LIPA2_HUMAN (1-1257): 1.83e-152: 493: 100.00		PTPRF_HUMAN (1-1912): 0: 1497: 67.03
+	Hs
		255244 LIPA3_HUMAN (1-1257): 1.49e-110: 377: 55.59		PTPRS_HUMAN (1-1912): 0: 1555: 71.33
+	Hs
		1025279 LIPA1_HUMAN (1-1257): 6.82e-109: 372: 62.89		PTPRS_HUMAN (1-1912): 0: 1555: 71.33
+	Hs
		255234 LIPA3_HUMAN (1-1257): 1.49e-110: 377: 55.59		PTPRF_HUMAN (1-1912): 0: 1497: 67.03
+	Hs
		489956 LIPA1_HUMAN (1-1257): 6.82e-109: 372: 62.89		PTPRF_HUMAN (1-1912): 0: 1497: 67.03
+	Dm
		114417 M9PCD4_DROME (1-1182): 6.32e-99: 345: 42.56		LAR_DROME (13-1352): 5.19e-168: 566: 33.33
+	Dm
		561777 Q9VM93_DROME (1-1182): 1.09e-95: 335: 42.48		LAR_DROME (13-1352): 5.19e-168: 566: 33.33
+	Dm
		65322 A8DYM0_DROME (877-1229): 3.16e-88: 313: 31.03		LAR_DROME (13-1352): 5.19e-168: 566: 33.33
+	Hs
		617154 MRCKB_HUMAN (4-315): 1.39e-11: 71.4: 12.65		PTPRG_HUMAN (833-1909): 0: 716: 25.56
+	Hs
		660856 MRCKA_HUMAN (225-853): 1.12e-14: 81.6: 13.54		PTPRM_HUMAN (332-987): 8.72e-35: 148: 14.26