HitPredict

Interactor 1: PDCD6 (O75340)
Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)
Gene: PDCD6

Interactor 2: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	16132846
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, EF-hand_7~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0097190 - apoptotic signaling pathway
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1430
+	Mm
		192649 CAN1_MOUSE (19-188): 5.68e-53: 181: 24.19		KCC2A_MOUSE (1-383): 5.07e-120: 385: 29.17
+	At
		626378 CML12_ARATH (4-158): 2.98e-38: 135: 16.11		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	Hs
		484108 CALM3_HUMAN (91-189): 1.6e-26: 100: 20.76		ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42
+	Dm
		906661 CALM_DROME (91-189): 5.29e-26: 99.1: 20.76		KCC2A_DROME (8-414): 4.43e-119: 384: 29.05
+	Hs
		483947 CALM1_HUMAN (91-189): 1.6e-26: 100: 20.76		KCC1D_HUMAN (2-325): 9.17e-120: 381: 35.39
+	At
		886601 CALM7_ARATH (90-189): 3.74e-25: 96.8: 22.43		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	At
		976670 CALM6_ARATH (90-189): 4.03e-25: 96.8: 22.43		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	At
		483143 CALM4_ARATH (91-189): 5.45e-25: 96.4: 22.64		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	Dm
		906677 CALM_DROME (91-189): 5.29e-26: 99.1: 20.76		Q7JMV3_DROME (5-369): 3.1e-119: 380: 31.76
+	Hs
		648542 CALL3_HUMAN (94-189): 3.78e-25: 96.8: 18.45		KCC1D_HUMAN (2-325): 9.17e-120: 381: 35.39
+	Hs
		483928 CALM1_HUMAN (91-189): 1.6e-26: 100: 20.76		KCC2D_HUMAN (2-383): 1.06e-116: 377: 27.94
+	Hs
		484002 CALM2_HUMAN (91-189): 1.6e-26: 100: 20.76		KCC2D_HUMAN (2-383): 1.06e-116: 377: 27.94
+	Hs
		484120 CALM3_HUMAN (91-189): 1.6e-26: 100: 20.76		KCC2D_HUMAN (2-383): 1.06e-116: 377: 27.94
+	Hs
		483929 CALM1_HUMAN (91-189): 1.6e-26: 100: 20.76		KCC1A_HUMAN (7-319): 5.17e-118: 376: 38.02
+	Hs
		648500 CALL3_HUMAN (94-189): 3.78e-25: 96.8: 18.45		KCC1A_HUMAN (7-319): 5.17e-118: 376: 38.02
+	At
		188340 CML8_ARATH (90-179): 7.06e-22: 88.3: 24.74		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	At
		1154717 CDPKW_ARATH (28-118): 9.67e-13: 67.5: 27.47		CDPKW_ARATH (7-362): 5.56e-119: 384: 32.69
+	Dm
		54870 CALM_DROME (91-189): 5.29e-26: 99.1: 20.76		A1ZA72_DROME (17-310): 6.12e-64: 243: 41.95