HitPredict

Interactor 1: PROP1 (O75360)
Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor)
Gene: PROP1

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20181723
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 226 Hs			1 770
+	Hs
		620142 PAX7_HUMAN (52-223): 2.86e-32: 124: 28.02		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980618 ISX_HUMAN (1-225): 3.64e-34: 124: 24.34		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		641377 PAX6_HUMAN (19-224): 2.6e-30: 117: 24.77		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		620144 PAX7_HUMAN (52-223): 2.86e-32: 124: 28.02		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		980936 ISX_HUMAN (1-225): 3.64e-34: 124: 24.34		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Mm
		623700 PAX3_MOUSE (10-224): 3.08e-30: 118: 21.88		TLE4_MOUSE (1-770): 0: 563: 86.27
+	Hs
		641379 PAX6_HUMAN (19-224): 2.6e-30: 117: 24.77		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		620143 PAX7_HUMAN (52-223): 2.86e-32: 124: 28.02		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		980762 ISX_HUMAN (1-225): 3.64e-34: 124: 24.34		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		641378 PAX6_HUMAN (19-224): 2.6e-30: 117: 24.77		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		260301 PROP1_HUMAN (1-226): 2.48e-36: 129: 100.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		620146 PAX7_HUMAN (52-223): 2.86e-32: 124: 28.02		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		993441 ISX_HUMAN (1-225): 3.64e-34: 124: 24.34		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		641385 PAX6_HUMAN (19-224): 2.6e-30: 117: 24.77		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Ce
		137665 UNC4_CAEEL (16-214): 2.02e-34: 124: 25.63		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Mm
		1376719 MIXL1_MOUSE (16-170): 5.08e-37: 131: 36.97		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Hs
		245559 PAX7_HUMAN (52-223): 2.86e-32: 124: 28.02		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Mm
		192307 ALX4_MOUSE (13-207): 2.55e-31: 119: 26.15		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Hs
		245563 PAX6_HUMAN (19-224): 2.6e-30: 117: 24.77		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		620138 PAX7_HUMAN (52-223): 2.86e-32: 124: 28.02		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37