HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005730 - nucleolus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 454
+	Hs
		348103 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		260704 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379969 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		347244 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		345670 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		345765 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		260819 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67
+	Hs
		346915 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		379580 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379457 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40