HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000793 - condensed chromosome GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 215
+	Hs
		260757 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SP100_HUMAN (25-178): 1.23e-34: 131: 87.66
+	Hs
		260994 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66
+	Hs
		449827 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00
+	Hs
		260795 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91
+	Hs
		996939 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		449762 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00
+	Hs
		449745 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00
+	Hs
		643395 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		HMGB2_HUMAN (1-187): 7e-43: 145: 82.89
+	Hs
		643357 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		HMGB2_HUMAN (1-187): 7e-43: 145: 82.89
+	Hs
		996861 MACD1_HUMAN (172-363): 9.08e-66: 213: 22.56		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		555429 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		996754 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		996856 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		391670 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		996711 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		996730 H2A3_HUMAN (1-126): 8.92e-65: 203: 62.79		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		594829 H2A1D_HUMAN (1-126): 1.88e-64: 203: 62.02		SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91
+	Hs
		555655 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69
+	Hs
		1151386 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69
+	Hs
		391917 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69