HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0019899 - enzyme binding GO:0019901 - protein kinase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 758
+	Hs
		497703 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		51240 MACD2_HUMAN (193-366): 1.89e-69: 225: 25.99		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496230 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497504 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		391521 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497450 H2A1H_HUMAN (1-125): 1.07e-64: 203: 62.50		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497112 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		69274 H2AJ_RAT (1-122): 9.64e-64: 201: 64.00		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Rn
		69275 H2AJ_RAT (1-122): 9.64e-64: 201: 64.00		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Hs
		654009 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		555463 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		554260 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84
+	Hs
		152575 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		1273164 H2A1H_HUMAN (1-125): 1.07e-64: 203: 62.50		PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93
+	Hs
		391802 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91