HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 17158748
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 765
+	Hs
		508751 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508606 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508682 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		470243 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		555561 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		DC2I1_HUMAN (12-216): 5.31e-09: 62: 13.25
+	Hs
		555503 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92
+	Sc
		388069 H2A2_YEAST (14-123): 1.54e-41: 144: 67.27		TOP1_YEAST (600-765): 7.36e-26: 115: 34.88
+	Sc
		388068 H2A1_YEAST (14-123): 2.85e-41: 143: 67.27		TOP1_YEAST (600-765): 7.36e-26: 115: 34.88