HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24457600, 28242625
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045814 - negative regulation of gene expression, epigenetic GO:1990841 - promoter-specific chromatin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 326
+	Hs
		260862 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		TRI26_HUMAN (5-210): 1e-49: 175: 16.59
+	Hs
		555322 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		391572 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		470285 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717932 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		260985 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1019374 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		TRI26_HUMAN (5-210): 1e-49: 175: 16.59
+	Hs
		555627 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		391879 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		470533 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		555611 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1216249 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1151374 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1185208 H2A3_HUMAN (1-126): 8.92e-65: 203: 62.79		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		391856 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		470514 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		555425 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		391666 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		282515 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282470 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00