HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: HMGA2 (P52926)
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)
Gene: HMGA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36835656
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000228 - nuclear chromosome GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0031492 - nucleosomal DNA binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 109
+	Mm
		857885 H2AY_MOUSE (1-369): 5.69e-165: 467: 98.10		HMGA2_MOUSE (1-109): 4.6e-41: 133: 95.41
+	Hs
		555367 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		HMGA2_HUMAN (1-109): 6.26e-43: 137: 100.00
+	Hs
		857497 H2A1C_HUMAN (1-126): 5.97e-65: 204: 62.79		HMGA2_HUMAN (1-109): 6.26e-43: 137: 100.00
+	Hs
		857503 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		HMGA2_HUMAN (1-109): 6.26e-43: 137: 100.00
+	Mm
		650182 H2AX_MOUSE (1-142): 7.49e-66: 206: 60.69		HMGA2_MOUSE (1-109): 4.6e-41: 133: 95.41
+	Hs
		857476 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		HMGA2_HUMAN (1-109): 6.26e-43: 137: 100.00
+	Mm
		857682 H2A3_MOUSE (1-126): 8.92e-65: 203: 62.79		HMGA2_MOUSE (1-109): 4.6e-41: 133: 95.41