HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: HDGR2 (Q7Z4V5)
Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
Gene: HDGFL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28242625, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus GO:0006281 - DNA repair
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 671
+	Hs
		261003 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		NSD3_HUMAN (4-413): 2.6e-62: 227: 11.66
+	Hs
		1190732 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00
+	Hs
		260680 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		PSIP1_HUMAN (1-553): 1.35e-54: 197: 23.49
+	Hs
		260808 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		261039 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		1349695 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		260805 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78
+	Hs
		1115591 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10
+	Hs
		850992 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78
+	Hs
		555526 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00
+	Hs
		331860 H2A1C_HUMAN (1-126): 5.97e-65: 204: 62.79		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		331703 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		331824 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Mm
		650197 H2AX_MOUSE (1-142): 7.49e-66: 206: 60.69		PSIP1_MOUSE (1-553): 5.28e-57: 203: 24.64
+	Hs
		555365 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		855539 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98
+	Hs
		555690 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		391965 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24
+	Hs
		391730 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10
+	Hs
		555503 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		NIPBL_HUMAN (100-662): 1.42e-17: 89.7: 16.10