HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: UBP48 (Q86UV5)
Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)
Gene: USP48

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28242625, 33903120
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 1035
+	Hs
		555529 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		UBP48_HUMAN (1-1035): 0: 1274: 100.00
+	Hs
		391769 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		UBP48_HUMAN (1-1035): 0: 1274: 100.00
+	Hs
		1087036 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP48_HUMAN (1-1035): 0: 1274: 100.00
+	Mm
		1113505 H2A1H_MOUSE (1-125): 1.14e-64: 203: 62.50		UBP48_MOUSE (1-1035): 0: 1245: 92.03
+	Hs
		261028 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		UBP36_HUMAN (15-525): 2.42e-103: 351: 18.10
+	Hs
		1349689 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		UBP36_HUMAN (15-525): 2.42e-103: 351: 18.10
+	Hs
		555508 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		U17L2_HUMAN (15-532): 2.91e-111: 356: 20.23
+	Hs
		391943 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		UBP36_HUMAN (15-525): 2.42e-103: 351: 18.10
+	Hs
		1312240 H2AJ_HUMAN (1-125): 1.21e-63: 200: 62.50		UBP36_HUMAN (15-525): 2.42e-103: 351: 18.10
+	Hs
		555577 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		UBP7_HUMAN (66-487): 5.02e-100: 341: 26.05
+	Hs
		391829 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		UBP7_HUMAN (66-487): 5.02e-100: 341: 26.05
+	Hs
		1087074 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP7_HUMAN (66-487): 5.02e-100: 341: 26.05
+	Hs
		259285 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP12_HUMAN (54-422): 1.09e-100: 323: 22.42
+	Hs
		905382 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP46_HUMAN (54-421): 7.22e-101: 323: 22.73
+	Hs
		271018 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		UBP2_HUMAN (38-425): 1.46e-95: 317: 20.98
+	Hs
		391991 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		UBP3_HUMAN (12-430): 3.93e-96: 316: 19.38
+	Hs
		271104 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP2_HUMAN (38-425): 1.46e-95: 317: 20.98
+	Hs
		391971 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		UBP22_HUMAN (16-400): 5.16e-95: 313: 19.38
+	Hs
		1087135 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP22_HUMAN (16-400): 5.16e-95: 313: 19.38
+	Hs
		1087139 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		UBP20_HUMAN (21-199): 3.28e-29: 128: 17.44