HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28564596
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-RING_6
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0046982 - protein heterodimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 777
+	Hs
		555617 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		391861 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		1087090 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		260693 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		TNKS1_HUMAN (364-552): 9.86e-28: 122: 23.98
+	Hs
		260971 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1293196 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		555536 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		391781 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		470446 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		ANKH1_HUMAN (114-664): 2.01e-66: 242: 14.16
+	Hs
		555510 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BCOR_HUMAN (152-543): 1.16e-44: 176: 23.93
+	Hs
		555597 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1151369 H2A2A_HUMAN (1-126): 8.18e-65: 203: 63.57		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		391842 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		470504 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1087083 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1293188 H2AJ_HUMAN (1-125): 1.21e-63: 200: 62.50		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1087014 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		TNI3K_HUMAN (452-551): 1.71e-15: 82.9: 21.64
+	Hs
		1237344 H2A1H_HUMAN (1-125): 1.07e-64: 203: 62.50		ANR31_HUMAN (423-543): 1.48e-11: 70.5: 38.02