HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	28242625, 21555454
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET, AWS~Histone_H2A_C
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 1437
+	Hs
		331860 H2A1C_HUMAN (1-126): 5.97e-65: 204: 62.79		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		331703 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		260808 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		203603 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		260972 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		260896 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080416 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		555365 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		855539 H2A1J_HUMAN (1-125): 5.25e-65: 204: 62.50		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		203730 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		203696 H2A2C_HUMAN (1-125): 9.23e-64: 201: 63.28		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		555602 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		470506 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		470560 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		1080241 H2A1H_HUMAN (1-125): 1.07e-64: 203: 62.50		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		391719 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		470396 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		391662 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		470359 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		391802 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75