HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: CHD8 (Q9HCK8)
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Gene: CHD8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28242625
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 2581
+	Hs
		555654 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		CHD8_HUMAN (1-2581): 0: 2318: 100.00
+	Hs
		260883 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		1059910 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		229254 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		260763 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SMCA1_HUMAN (654-1705): 0: 875: 26.13
+	Hs
		260802 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		SMCA4_HUMAN (69-1478): 0: 806: 23.14
+	Hs
		1018640 H2A1H_HUMAN (1-125): 1.07e-64: 203: 62.50		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		391675 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		555466 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		1059717 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		1059795 H2A1H_HUMAN (1-125): 1.07e-64: 203: 62.50		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		391704 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		229296 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		229433 H2A2B_HUMAN (1-125): 5.78e-65: 204: 64.06		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		229279 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		555306 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		SMCA1_HUMAN (654-1705): 0: 875: 26.13
+	Hs
		555359 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		SMCA4_HUMAN (69-1478): 0: 806: 23.14
+	Hs
		151474 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		CHD2_HUMAN (373-1741): 0: 803: 25.76
+	Hs
		555358 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		SMCA2_HUMAN (101-1489): 0: 797: 22.14
+	Hs
		391728 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		CHD9_HUMAN (2104-2481): 1.87e-106: 385: 29.62