HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: ZMYD8 (Q9ULU4)
MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)
Gene: ZMYND8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	28242625, 31753913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 1 others more... GO:0090734 - site of DNA damage
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 1186
+	Hs
		1349695 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		ZMYD8_HUMAN (1-1186): 0: 1251: 100.00
+	Hs
		555690 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		ZMYD8_HUMAN (1-1186): 0: 1251: 100.00
+	Hs
		391965 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		ZMYD8_HUMAN (1-1186): 0: 1251: 100.00
+	Hs
		170185 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		TIF1A_HUMAN (38-288): 2.75e-50: 196: 24.44
+	Hs
		261003 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		NSD3_HUMAN (3-359): 2.43e-44: 177: 14.64
+	Hs
		261033 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		BAZ2A_HUMAN (82-251): 2.51e-37: 155: 18.50
+	Hs
		170498 H2AW_HUMAN (1-368): 1.41e-145: 418: 66.04		TIF1A_HUMAN (38-288): 2.75e-50: 196: 24.44
+	Hs
		260859 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		BPTF_HUMAN (57-256): 6.93e-34: 144: 19.81
+	Hs
		260921 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		PB1_HUMAN (115-379): 7.74e-19: 95.1: 11.57
+	Hs
		331860 H2A1C_HUMAN (1-126): 5.97e-65: 204: 62.79		NSD2_HUMAN (17-359): 5.44e-55: 212: 17.31
+	Hs
		555681 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BAZ2A_HUMAN (82-251): 2.51e-37: 155: 18.50
+	Hs
		555661 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BAZ1A_HUMAN (5-252): 1.74e-36: 152: 14.63
+	Hs
		391923 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		BAZ1A_HUMAN (5-252): 1.74e-36: 152: 14.63
+	Hs
		555434 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		BPTF_HUMAN (57-256): 6.93e-34: 144: 19.81
+	Hs
		555528 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		PB1_HUMAN (115-379): 7.74e-19: 95.1: 11.57
+	Hs
		391768 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		PB1_HUMAN (115-379): 7.74e-19: 95.1: 11.57
+	Hs
		555569 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		KAT2A_HUMAN (142-251): 1.37e-13: 77.6: 27.03
+	Hs
		555570 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		KAT2B_HUMAN (142-251): 2.88e-13: 76.5: 27.93
+	Hs
		391824 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		KAT2A_HUMAN (142-251): 1.37e-13: 77.6: 27.03
+	Hs
		391825 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		KAT2B_HUMAN (142-251): 2.88e-13: 76.5: 27.93