HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: FINC (P02751)
Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
Gene: FN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	19738201
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CH~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2602 Hs			1 2477
+	Hs
		362811 FLNA_HUMAN (1-2602): 0: 2661: 69.59		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		234453 FLNB_HUMAN (1-2602): 0: 2855: 100.00		DSCAM_HUMAN (1269-2389): 1.73e-81: 302: 9.48
+	Hs
		363145 FLNC_HUMAN (6-2602): 0: 1470: 35.38		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		598253 FLNA_HUMAN (1-2602): 0: 2661: 69.59		TITIN_HUMAN (1443-1642): 3.25e-10: 68.6: 9.86
+	Hs
		363087 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		211454 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		363077 PGBM_HUMAN (1199-2602): 3.08e-68: 259: 13.76		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		234468 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		DSCAM_HUMAN (1269-2389): 1.73e-81: 302: 9.48
+	Hs
		234502 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		DSCAM_HUMAN (1269-2389): 1.73e-81: 302: 9.48
+	Hs
		211436 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		DSCAM_HUMAN (1269-2389): 1.73e-81: 302: 9.48
+	Ce
		1095237 Q23158_CAEEL (5-241): 1.35e-103: 358: 33.75		Q9UB29_CAEEL (574-1918): 1.38e-77: 290: 16.57
+	Ce
		1095236 Q23158_CAEEL (5-241): 1.35e-103: 358: 33.75		Q9UB28_CAEEL (574-1918): 6.27e-77: 288: 16.57
+	Hs
		725715 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		TENN_HUMAN (581-1107): 2.67e-65: 247: 23.15
+	Mm
		472767 ACTN1_MOUSE (5-364): 6.66e-117: 397: 27.15		PTPRQ_MOUSE (2231-2391): 2.01e-12: 75.5: 6.10
+	Hs
		993278 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		TITIN_HUMAN (1443-1642): 3.25e-10: 68.6: 9.86
+	Hs
		521586 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		TITIN_HUMAN (1443-1642): 3.25e-10: 68.6: 9.86
+	Hs
		725681 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		TITIN_HUMAN (1443-1642): 3.25e-10: 68.6: 9.86
+	Hs
		211629 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		TITIN_HUMAN (1443-1642): 3.25e-10: 68.6: 9.86
+	Dm
		574825 ACTN_DROME (9-259): 5.05e-96: 336: 32.55		TITIN_DROME (1910-2401): 6.36e-13: 77.5: 10.47
+	Dm
		1337379 FLNA_DROME (2172-2601): 1.6e-61: 237: 26.01		TITIN_DROME (1910-2401): 6.36e-13: 77.5: 10.47