HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	26618866, 31324722, 29924966
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2602 Hs			1 1480
+	Hs
		528541 FLNA_HUMAN (1-2602): 0: 2661: 69.59		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529110 FLNC_HUMAN (6-2602): 0: 1470: 35.38		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529029 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		521456 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528678 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528984 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		211482 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529917 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		CFTR_HUMAN (1-1480): 0: 1031: 100.00