HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2602 Hs			1 377
+	Hs
		261205 FLNB_HUMAN (1-2602): 0: 2855: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		261240 FLNB_HUMAN (1-2602): 0: 2855: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		298948 FLNA_HUMAN (1-2602): 0: 2661: 69.59		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		597968 FLNA_HUMAN (1-2602): 0: 2661: 69.59		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		412006 FLNA_HUMAN (1-2602): 0: 2661: 69.59		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		522770 FLNA_HUMAN (1-2602): 0: 2661: 69.59		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		598047 FLNA_HUMAN (1-2602): 0: 2661: 69.59		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		557690 FLNC_HUMAN (6-2602): 0: 1470: 35.38		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		655367 FLNC_HUMAN (6-2602): 0: 1470: 35.38		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		412192 FLNC_HUMAN (6-2602): 0: 1470: 35.38		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		924572 FLNC_HUMAN (6-2602): 0: 1470: 35.38		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Mm
		1113251 ACTN1_MOUSE (5-364): 6.66e-117: 397: 27.15		SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85
+	Hs
		298946 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		211443 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		129277 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		521454 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		521521 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		963335 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		924482 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		211480 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32