HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: ITB6 (P18564)
Integrin beta-6
Gene: ITGB6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11807098
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filamin~Integrin_b_cyt
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2602 Hs			1 788
+	Hs
		261181 FLNB_HUMAN (1-2602): 0: 2855: 100.00		ITB1_HUMAN (3-777): 0: 727: 41.26
+	Mm
		222550 FLNB_MOUSE (1-2602): 0: 2844: 95.85		ITB3_MOUSE (19-776): 0: 712: 49.41
+	Hs
		261179 FLNB_HUMAN (1-2602): 0: 2855: 100.00		ITB3_HUMAN (21-776): 0: 690: 50.20
+	Mm
		515662 FLNB_MOUSE (1-2602): 0: 2844: 95.85		ITB2_MOUSE (17-775): 0: 638: 38.34
+	Hs
		577567 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ITB6_HUMAN (1-788): 0: 736: 100.00
+	Mm
		447108 FLNA_MOUSE (1-2602): 0: 2668: 69.21		ITB1_MOUSE (3-777): 0: 728: 41.64
+	Hs
		403783 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ITB1_HUMAN (3-777): 0: 727: 41.26
+	Mm
		222557 FLNA_MOUSE (1-2602): 0: 2668: 69.21		ITB3_MOUSE (19-776): 0: 712: 49.41
+	Hs
		396566 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ITB3_HUMAN (21-776): 0: 690: 50.20
+	Hs
		597965 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ITB7_HUMAN (15-775): 0: 647: 38.52
+	Mm
		515666 FLNA_MOUSE (1-2602): 0: 2668: 69.21		ITB2_MOUSE (17-775): 0: 638: 38.34
+	Hs
		556411 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ITB4_HUMAN (5-706): 0: 614: 31.15
+	Mm
		222569 FLNC_MOUSE (6-2602): 0: 1470: 35.32		ITB3_MOUSE (19-776): 0: 712: 49.41
+	Mm
		515676 FLNC_MOUSE (6-2602): 0: 1470: 35.32		ITB2_MOUSE (17-775): 0: 638: 38.34
+	Gg
		396530 ACTN1_CHICK (5-364): 9.38e-118: 399: 27.15		ITB1_CHICK (6-777): 0: 727: 41.11
+	Hs
		403752 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		ITB1_HUMAN (3-777): 0: 727: 41.26
+	Rn
		88558 D3ZCV0_RAT (5-364): 1.68e-116: 395: 26.61		ITB1_RAT (3-777): 0: 726: 41.21
+	Mm
		222535 SPTB2_MOUSE (6-367): 4.85e-108: 389: 28.65		ITB3_MOUSE (19-776): 0: 712: 49.41
+	Mm
		515654 SPTB2_MOUSE (6-367): 4.85e-108: 389: 28.65		ITB2_MOUSE (17-775): 0: 638: 38.34
+	Hs
		725715 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		TENN_HUMAN (538-664): 1.18e-20: 99.7: 26.21