HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: VCAM1 (P19320)
Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Gene: VCAM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	19738201, 22623428
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2602 Hs			1 739
+	Hs
		581420 FLNA_HUMAN (1-2602): 0: 2661: 69.59		VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00
+	Hs
		234453 FLNB_HUMAN (1-2602): 0: 2855: 100.00		DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87
+	Hs
		598253 FLNA_HUMAN (1-2602): 0: 2661: 69.59		TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24
+	Hs
		581728 FLNC_HUMAN (6-2602): 0: 1470: 35.38		VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00
+	Hs
		581681 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00
+	Hs
		211493 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00
+	Hs
		581890 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		VCAM1_HUMAN (1-739): 2.2e-152: 462: 100.00
+	Rn
		88917 ACTN1_RAT (5-364): 2.29e-117: 398: 27.15		D4A435_RAT (112-712): 2.29e-40: 161: 16.03
+	Hs
		234468 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87
+	Hs
		234502 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87
+	Hs
		211436 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87
+	Dm
		52391 FLNA_DROME (2172-2601): 1.6e-61: 237: 26.01		A1Z7J1_DROME (35-621): 5.09e-63: 231: 17.83
+	Hs
		993278 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24
+	Hs
		521638 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		ICAM5_HUMAN (307-697): 2.93e-10: 65.7: 20.87
+	Hs
		521586 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24
+	Hs
		725681 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24
+	Hs
		211629 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		TITIN_HUMAN (602-739): 2.77e-09: 63.1: 17.24
+	Hs
		234595 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		DSCAM_HUMAN (10-207): 2.99e-15: 82.3: 12.87
+	Dm
		65342 Q9W4Y3_DROME (1136-2158): 3.74e-24: 114: 10.66		OBSCN_DROME (597-710): 6.63e-10: 65: 13.22