HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36652389
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~CH, CH~Filamin, Filamin~Filamin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030018 - Z disc and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2602 Hs			1 2725
+	Hs
		598114 FLNA_HUMAN (1-2602): 0: 2661: 69.59		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		261201 FLNB_HUMAN (1-2602): 0: 2855: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261164 FLNB_HUMAN (1-2602): 0: 2855: 100.00		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		1052874 FLNC_HUMAN (6-2602): 0: 1470: 35.38		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		597957 FLNA_HUMAN (1-2602): 0: 2661: 69.59		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261173 FLNB_HUMAN (1-2602): 0: 2855: 100.00		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		211497 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		598070 FLNA_HUMAN (1-2602): 0: 2661: 69.59		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		362811 FLNA_HUMAN (1-2602): 0: 2661: 69.59		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		598253 FLNA_HUMAN (1-2602): 0: 2661: 69.59		TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78
+	Dm
		1181837 Q7KSF4_DROME (5-2375): 0: 1469: 35.03		FLNA_DROME (758-2724): 0: 1012: 33.19
+	Hs
		363145 FLNC_HUMAN (6-2602): 0: 1470: 35.38		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		521530 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		725648 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00
+	Hs
		211571 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		993246 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		ACTN3_HUMAN (23-388): 4.53e-120: 406: 27.63
+	Hs
		70394 B2R8Y4_HUMAN (5-364): 4.42e-118: 400: 26.88		B2R8Y4_HUMAN (23-388): 3.96e-120: 406: 27.63
+	Hs
		993278 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78