HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: MYPC2 (Q14324)
Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)
Gene: MYBPC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	23414517
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CH~fn3
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2602 Hs			1 1141
+	Hs
		234453 FLNB_HUMAN (1-2602): 0: 2855: 100.00		DSCAM_HUMAN (460-1140): 4.36e-45: 180: 12.85
+	Hs
		255374 FLNB_HUMAN (1-2602): 0: 2855: 100.00		OBSL1_HUMAN (271-435): 2.57e-09: 63.9: 25.90
+	Hs
		598253 FLNA_HUMAN (1-2602): 0: 2661: 69.59		TITIN_HUMAN (1007-1139): 1.39e-11: 71.8: 23.31
+	Hs
		255501 FLNA_HUMAN (1-2602): 0: 2661: 69.59		OBSL1_HUMAN (271-435): 2.57e-09: 63.9: 25.90
+	Hs
		1052875 FLNC_HUMAN (6-2602): 0: 1470: 35.38		MYPC2_HUMAN (1-1141): 0: 688: 100.00
+	Hs
		1052877 FLNC_HUMAN (6-2602): 0: 1470: 35.38		MYPC3_HUMAN (1-639): 2.74e-35: 148: 12.23
+	Hs
		255772 FLNC_HUMAN (6-2602): 0: 1470: 35.38		OBSL1_HUMAN (271-435): 2.57e-09: 63.9: 25.90
+	Hs
		725655 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		MYPC2_HUMAN (1-1141): 0: 688: 100.00
+	Hs
		234468 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		DSCAM_HUMAN (460-1140): 4.36e-45: 180: 12.85
+	Hs
		234502 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		DSCAM_HUMAN (460-1140): 4.36e-45: 180: 12.85
+	Hs
		211436 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		DSCAM_HUMAN (460-1140): 4.36e-45: 180: 12.85
+	Hs
		725635 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		MYOM2_HUMAN (77-540): 1.74e-20: 100: 15.08
+	Hs
		993278 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		TITIN_HUMAN (1007-1139): 1.39e-11: 71.8: 23.31
+	Hs
		521586 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		TITIN_HUMAN (1007-1139): 1.39e-11: 71.8: 23.31
+	Hs
		725681 ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61		TITIN_HUMAN (1007-1139): 1.39e-11: 71.8: 23.31
+	Hs
		255470 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		OBSL1_HUMAN (271-435): 2.57e-09: 63.9: 25.90
+	Hs
		211629 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		TITIN_HUMAN (1007-1139): 1.39e-11: 71.8: 23.31
+	Hs
		211438 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		OBSL1_HUMAN (271-435): 2.57e-09: 63.9: 25.90
+	Dm
		574825 ACTN_DROME (9-259): 5.05e-96: 336: 32.55		TITIN_DROME (980-1140): 3.3e-17: 90.3: 20.99
+	Dm
		1337379 FLNA_DROME (2172-2601): 1.6e-61: 237: 26.01		TITIN_DROME (980-1140): 3.3e-17: 90.3: 20.99