HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2602 Hs			1 530
+	Hs
		261174 FLNB_HUMAN (1-2602): 0: 2855: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		598256 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368984 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487127 FLNA_HUMAN (1-2602): 0: 2661: 69.59		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		1052915 FLNC_HUMAN (6-2602): 0: 1470: 35.38		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		993279 ACTN3_HUMAN (5-364): 1.21e-118: 402: 26.88		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		521591 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211633 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368893 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369420 SPTB2_HUMAN (6-367): 4.86e-108: 389: 28.65		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		211456 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		521532 ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		957553 PGBM_HUMAN (1199-2602): 3.08e-68: 259: 13.76		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211472 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		1269937 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370715 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		580490 ACTN2_MOUSE (5-364): 2.6e-116: 395: 26.61		ANDR_MOUSE (149-407): 1.53e-38: 152: 33.70
+	Hs
		211471 ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		510045 MACF1_HUMAN (16-239): 9.3e-35: 149: 40.69		ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65