HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: NR1I2 (O75469)
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)
Gene: NR1I2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	18978041
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0016922 - nuclear receptor binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 434
+	Hs
		261386 NCOR1_HUMAN (1-2440): 0: 780: 100.00		VDR_HUMAN (19-434): 6.56e-95: 293: 39.49
+	Hs
		261450 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H2_HUMAN (4-431): 7.44e-94: 292: 26.10
+	Hs
		261399 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RXRA_HUMAN (2-428): 2.34e-93: 291: 18.64
+	Hs
		261493 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H3_HUMAN (16-431): 2.38e-92: 287: 25.60
+	Hs
		261436 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40
+	Hs
		261382 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THA_HUMAN (22-402): 4.56e-90: 283: 25.52
+	Hs
		261474 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARD_HUMAN (36-430): 2.23e-89: 279: 24.00
+	Hs
		261381 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARA_HUMAN (7-432): 1.15e-87: 276: 26.57
+	Hs
		261383 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THB_HUMAN (2-429): 6.98e-88: 276: 25.86
+	Hs
		261429 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HNF4A_HUMAN (13-429): 1.76e-86: 273: 20.00
+	Hs
		261369 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81
+	Hs
		261568 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H4_HUMAN (2-431): 2.51e-85: 271: 26.10
+	Hs
		261481 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARA_HUMAN (5-429): 4e-85: 269: 23.45
+	Hs
		261390 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARG_HUMAN (39-429): 2.59e-84: 267: 26.14
+	Hs
		261424 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARG_HUMAN (31-431): 5.85e-84: 267: 24.14
+	Mm
		723171 NCOR1_MOUSE (1-2440): 0: 701: 89.79		PPARD_MOUSE (5-431): 3.55e-85: 269: 22.45
+	Xl
		546251 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THAA_XENLA (4-429): 1.63e-87: 274: 25.06
+	Xl
		574911 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THBA_XENLA (23-431): 8.6e-86: 268: 25.36
+	Mm
		193216 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		NR1I3_MOUSE (31-428): 4.29e-106: 319: 38.85
+	Hs
		130339 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		NR5A2_HUMAN (6-428): 1.16e-91: 289: 20.25