HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	12663743, 33961781, 15604093, 26120082
Identification Methods	two hybrid, affinity chromatography technology, chromatin immunoprecipitation assay, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 447
+	Hs
		261399 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RXRA_HUMAN (6-445): 5.73e-129: 382: 22.89
+	Hs
		261450 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H2_HUMAN (12-447): 3.47e-127: 377: 61.96
+	Hs
		261369 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		261429 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HNF4A_HUMAN (74-443): 1.56e-112: 340: 26.08
+	Hs
		261381 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARA_HUMAN (15-447): 1.17e-111: 338: 29.00
+	Hs
		261424 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARG_HUMAN (69-443): 3.18e-108: 330: 27.64
+	Hs
		261386 NCOR1_HUMAN (1-2440): 0: 780: 100.00		VDR_HUMAN (95-446): 9.2e-109: 329: 32.21
+	Hs
		261568 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H4_HUMAN (5-446): 5.61e-108: 329: 34.23
+	Hs
		261390 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARG_HUMAN (17-447): 8.95e-108: 328: 29.17
+	Hs
		261557 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR2_HUMAN (2-446): 1.53e-101: 314: 19.69
+	Hs
		261481 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARA_HUMAN (5-443): 6.93e-102: 313: 25.43
+	Hs
		261383 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THB_HUMAN (36-444): 7.14e-98: 302: 28.81
+	Hs
		261382 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THA_HUMAN (95-410): 1.92e-49: 177: 34.05
+	Hs
		261355 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1I2_HUMAN (75-445): 8.74e-49: 174: 29.67
+	Hs
		261474 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARD_HUMAN (95-443): 7.31e-38: 144: 29.95
+	Xl
		574911 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THBA_XENLA (80-444): 1.22e-102: 312: 30.05
+	Mm
		723171 NCOR1_MOUSE (1-2440): 0: 701: 89.79		PPARD_MOUSE (95-443): 1.98e-39: 149: 30.75
+	Xl
		546251 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THAA_XENLA (72-447): 4.18e-98: 302: 30.49
+	Mm
		193216 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		NR1I3_MOUSE (94-442): 2.6e-48: 171: 30.81
+	Hs
		265885 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		NR1I2_HUMAN (75-445): 8.74e-49: 174: 29.67