HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: NR1D2 (Q14995)
Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
Gene: NR1D2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9611234
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 579
+	Hs
		261402 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1D1_HUMAN (4-577): 1.91e-135: 409: 48.10
+	Hs
		261436 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR2C2_HUMAN (30-574): 1e-117: 363: 18.85
+	Hs
		261399 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RXRA_HUMAN (12-338): 8.25e-52: 186: 22.59
+	Hs
		261369 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR1_HUMAN (204-576): 1.49e-45: 171: 13.15
+	Hs
		261390 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARG_HUMAN (44-178): 1.27e-46: 171: 40.00
+	Hs
		261381 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARA_HUMAN (13-178): 1.15e-45: 169: 36.47
+	Hs
		261383 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THB_HUMAN (60-293): 1.65e-43: 163: 29.66
+	Hs
		261493 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H3_HUMAN (12-252): 2.88e-43: 162: 23.27
+	Hs
		261450 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H2_HUMAN (12-187): 8.69e-42: 158: 29.35
+	Hs
		261424 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARG_HUMAN (412-576): 5.54e-27: 116: 38.69
+	Hs
		261474 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARD_HUMAN (413-576): 2.05e-25: 111: 39.16
+	Hs
		261481 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARA_HUMAN (413-570): 6.69e-25: 109: 37.50
+	Mm
		723171 NCOR1_MOUSE (1-2440): 0: 701: 89.79		PPARD_MOUSE (413-576): 4.15e-25: 110: 39.16
+	Hs
		130339 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		NR5A2_HUMAN (17-578): 1.01e-107: 335: 21.43
+	Xl
		546251 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THAA_XENLA (47-293): 2.78e-51: 183: 29.20
+	Xl
		574911 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THBA_XENLA (86-293): 2.33e-47: 171: 29.67
+	Hs
		370824 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		ESR1_HUMAN (204-576): 1.49e-45: 171: 13.15
+	Hs
		488042 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARA_HUMAN (13-178): 1.15e-45: 169: 36.47
+	Hs
		500380 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARB_HUMAN (74-211): 1.75e-45: 168: 37.68
+	Hs
		500510 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		THB_HUMAN (60-293): 1.65e-43: 163: 29.66