HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: HDAC7 (Q8WUI4)
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-)
Gene: HDAC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	11466315, 23752268
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 952
+	Hs
		261452 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HDAC4_HUMAN (20-939): 0: 958: 48.44
+	Hs
		261611 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HDAC9_HUMAN (20-892): 0: 869: 43.28
+	Hs
		261614 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HDAC5_HUMAN (20-950): 0: 850: 41.21
+	Hs
		1260208 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Mm
		1207909 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		HDAC7_MOUSE (1-952): 0: 986: 85.42
+	Hs
		880872 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDAC4_HUMAN (20-939): 0: 958: 48.44
+	Mm
		1112790 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		Q3UJF1_MOUSE (20-950): 0: 851: 41.88
+	Hs
		1357907 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDAC5_HUMAN (20-950): 0: 850: 41.21
+	Hs
		261500 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HDAC1_HUMAN (510-916): 1.27e-170: 507: 21.91
+	Hs
		177153 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Mm
		292414 NCOR1_MOUSE (1-2440): 0: 701: 89.79		HDAC3_MOUSE (518-951): 2.02e-161: 481: 20.00
+	Hs
		1038852 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDAC1_HUMAN (510-916): 1.27e-170: 507: 21.91
+	Hs
		1270546 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDAC2_HUMAN (513-948): 3.43e-167: 499: 20.71
+	Hs
		177416 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Hs
		1282247 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		HDA10_HUMAN (520-943): 1.36e-152: 467: 36.39
+	Hs
		1038768 RCOR3_HUMAN (417-809): 8.57e-87: 295: 18.92		HDAC1_HUMAN (510-916): 1.27e-170: 507: 21.91
+	Hs
		1270488 RCOR3_HUMAN (417-809): 8.57e-87: 295: 18.92		HDAC2_HUMAN (513-948): 3.43e-167: 499: 20.71
+	Hs
		177395 RCOR3_HUMAN (417-809): 8.57e-87: 295: 18.92		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Hs
		177402 RCOR1_HUMAN (360-717): 6.64e-75: 260: 19.40		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Dm
		1212082 Q9VYK0_DROME (144-534): 8.23e-71: 268: 35.35		Q8I9J6_DROME (44-490): 6.64e-68: 249: 19.84