HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: NR1H4 (Q96RI1)
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
Gene: NR1H4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18978041
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0005654 - nucleoplasm GO:0016922 - nuclear receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 486
+	Hs
		261369 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		261399 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RXRA_HUMAN (11-485): 4.19e-119: 358: 20.78
+	Hs
		261493 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H3_HUMAN (60-486): 1.64e-112: 341: 34.57
+	Hs
		261450 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H2_HUMAN (44-486): 5.33e-109: 332: 30.19
+	Hs
		261381 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61
+	Hs
		261424 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		261474 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARD_HUMAN (101-483): 2.03e-101: 312: 25.99
+	Hs
		261383 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THB_HUMAN (72-485): 1.08e-100: 311: 26.95
+	Hs
		261429 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HNF4A_HUMAN (113-483): 6.35e-100: 309: 23.14
+	Hs
		261557 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15
+	Hs
		261390 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARG_HUMAN (53-484): 7e-97: 301: 27.23
+	Hs
		261481 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARA_HUMAN (38-483): 1.4e-96: 301: 23.45
+	Mm
		723171 NCOR1_MOUSE (1-2440): 0: 701: 89.79		PPARD_MOUSE (68-485): 2.08e-94: 294: 24.49
+	Hs
		261382 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THA_HUMAN (134-444): 4.36e-41: 155: 33.43
+	Xl
		546251 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THAA_XENLA (105-486): 4.13e-99: 306: 27.44
+	Xl
		574911 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THBA_XENLA (119-485): 1.19e-99: 306: 28.80
+	Hs
		370824 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		500380 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARB_HUMAN (38-484): 9.82e-104: 319: 27.31
+	Hs
		488042 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61
+	Mm
		193216 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		NR1I3_MOUSE (133-482): 5.2e-38: 144: 30.89