HitPredict

Interactor 1: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Interactor 2: STX11 (O75558)
Syntaxin-11
Gene: STX11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~Syntaxin
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 141 Hs			1 287
+	Hs
		261664 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX1A_HUMAN (1-286): 2.81e-70: 220: 28.67
+	Dm
		1098086 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		STX1A_DROME (10-286): 7.18e-68: 214: 26.72
+	Hs
		261655 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX4_HUMAN (1-286): 1.54e-58: 190: 27.53
+	At
		1378372 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SY121_ARATH (17-278): 3.4e-54: 181: 18.59
+	At
		812702 VA722_ARATH (10-139): 9.81e-40: 134: 33.08		SY121_ARATH (17-278): 3.4e-54: 181: 18.59
+	Hs
		261658 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX3_HUMAN (1-276): 4.38e-55: 181: 30.44
+	At
		1352937 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SY122_ARATH (31-278): 2.72e-49: 167: 19.22
+	At
		1114744 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SY111_ARATH (1-278): 1.35e-47: 162: 17.25
+	Hs
		152121 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX16_HUMAN (13-276): 1.14e-49: 168: 16.17
+	At
		1352876 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SYP43_ARATH (7-285): 1.33e-45: 158: 12.98
+	At
		812689 VA722_ARATH (10-139): 9.81e-40: 134: 33.08		SY111_ARATH (1-278): 1.35e-47: 162: 17.25
+	At
		249598 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SYP41_ARATH (7-285): 2.04e-45: 157: 11.93
+	At
		1352985 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SYP42_ARATH (10-286): 8.53e-45: 156: 14.29
+	At
		1258650 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SY132_ARATH (11-278): 2.14e-44: 154: 18.55
+	Hs
		178330 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX7_HUMAN (56-275): 1e-44: 154: 15.25
+	At
		955702 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SYP22_ARATH (52-284): 1.35e-42: 148: 18.14
+	Hs
		261687 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX12_HUMAN (47-283): 7.51e-44: 152: 19.09
+	At
		955681 VA713_ARATH (7-138): 1.08e-39: 134: 25.76		SYP22_ARATH (52-284): 1.35e-42: 148: 18.14
+	Dm
		1097995 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		STX5_DROME (2-280): 2.25e-43: 155: 12.08
+	At
		955679 VA714_ARATH (6-138): 1.39e-37: 129: 27.07		SYP22_ARATH (52-284): 1.35e-42: 148: 18.14