HitPredict

Interactor 1: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	30833792, 35271311, 28514442, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 141 Hs			1 295
+	Hs
		261720 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		850546 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Dm
		1095560 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		873545 VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		873528 VAMP2_HUMAN (46-122): 9.98e-26: 95.5: 35.07		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Mm
		659546 VAMP2_MOUSE (46-122): 9.98e-26: 95.5: 35.07		SNAB_MOUSE (1-292): 6.03e-113: 329: 84.25
+	Hs
		873576 VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Dm
		577215 SYB_DROME (24-135): 9.5e-32: 112: 26.79		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Zm
		31296 A0A1D6KH00_MAIZE (10-138): 4.11e-41: 146: 28.68		A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80
+	Sc
		696608 NYV1_YEAST (11-136): 5.27e-27: 102: 25.00		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Sc
		605825 SEC22_YEAST (23-133): 3.08e-25: 97: 17.12		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Sc
		678143 SNC1_YEAST (42-119): 1.06e-23: 90.5: 30.77		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		261710 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		850592 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1178116 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Hs
		1079416 VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		926249 VAMP2_HUMAN (46-122): 9.98e-26: 95.5: 35.07		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		1306201 VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1178122 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		577238 SYB_DROME (24-135): 9.5e-32: 112: 26.79		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49