HitPredict

Interactor 1: TRIM3 (O75382)
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
Gene: TRIM3

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36634849, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030425 - dendrite
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 744 Hs			1 758
+	Rn
		250672 TRIM3_RAT (1-744): 0: 608: 98.12		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94106 TRIM3_RAT (1-744): 0: 608: 98.12		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		497564 TRIM2_HUMAN (1-744): 0: 565: 66.67		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496272 RO52_HUMAN (18-481): 1.33e-82: 272: 14.97		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Ce
		136810 LIN41_CAEEL (119-740): 4.67e-79: 276: 22.89		UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37
+	Hs
		496450 TRI23_HUMAN (18-169): 3.18e-13: 75.1: 27.78		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		654076 TRI33_HUMAN (21-323): 6.99e-57: 212: 20.50		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		1057027 TRI33_HUMAN (21-323): 6.99e-57: 212: 20.50		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		537122 TRI27_HUMAN (9-478): 8.29e-67: 231: 15.26		MAGL2_HUMAN (1-739): 1.99e-19: 95.9: 10.23
+	Hs
		1170080 TRI54_HUMAN (9-293): 5.88e-68: 229: 23.36		SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83
+	Hs
		170402 TIF1A_HUMAN (21-327): 8.05e-63: 229: 17.32		SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83
+	Mm
		1265761 TRI59_MOUSE (17-292): 1.08e-62: 216: 22.92		TARA_MOUSE (3-751): 2.63e-09: 63.2: 8.51
+	Dm
		1177266 Q7JUV6_DROME (14-424): 1.64e-38: 156: 17.06		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96