HitPredict

Interactor 1: TRIM3 (O75382)
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
Gene: TRIM3

Interactor 2: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	32296183, 24393003, 36481767, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 744 Hs			1 147
+	Hs
		262201 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84
+	Hs
		262167 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		262166 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		262192 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		262163 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Hs
		1318738 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84
+	Hs
		849440 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00
+	Hs
		919854 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		895906 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		1297367 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		1282345 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94
+	Hs
		851883 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Hs
		896539 TRIM2_HUMAN (1-744): 0: 565: 66.67		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83
+	Hs
		849316 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00
+	Hs
		919715 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		895783 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		1023317 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		1023307 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94
+	Hs
		851808 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Hs
		896429 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83