HitPredict

Interactor 1: TRIM3 (O75382)
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
Gene: TRIM3

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	36481767, 21143188
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 744 Hs			1 147
+	Hs
		262161 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		262167 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		262166 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		262192 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		262163 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		1318738 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		849440 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919854 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895906 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1297367 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1282345 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851883 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896539 TRIM2_HUMAN (1-744): 0: 565: 66.67		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		849316 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919715 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895783 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1023317 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1023307 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851808 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		896429 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53