HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Longin~Synaptobrevin, Synaptobrevin~Synaptobrevin
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 116
+	Dm
		115809 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18
+	Dm
		115796 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Hs
		306775 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Dm
		577225 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Sc
		605833 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		SNC2_YEAST (2-74): 6.15e-24: 90: 23.29
+	Hs
		850543 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Sc
		605883 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		NYV1_YEAST (9-81): 2.24e-21: 86.9: 21.92
+	Hs
		180776 YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Hs
		850567 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Dm
		1178144 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18
+	Dm
		577266 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Sc
		731090 YKT6_YEAST (31-188): 1.64e-44: 148: 24.54		NYV1_YEAST (9-81): 2.24e-21: 86.9: 21.92