HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: GOSR1 (O95249)
Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28)
Gene: GOSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 20562859
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0000139 - Golgi membrane GO:0005484 - SNAP receptor activity GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0015031 - protein transport GO:0030133 - transport vesicle and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 250
+	Hs
		92387 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		E9PCW1_HUMAN (1-250): 5.28e-111: 320: 99.20
+	Rn
		1125560 YKT6_RAT (30-188): 8.16e-53: 170: 23.13		GOSR1_RAT (1-250): 3.67e-114: 329: 98.40
+	Hs
		180777 YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13		GOSR1_HUMAN (1-250): 6.41e-114: 328: 100.00
+	Mm
		292030 YKT6_MOUSE (30-188): 1.21e-52: 169: 23.13		GOSR1_MOUSE (1-250): 2.64e-114: 329: 97.60
+	Dm
		115825 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		GOSR1_DROME (5-250): 8.4e-72: 221: 45.75
+	Dm
		1178120 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		GOSR1_DROME (5-250): 8.4e-72: 221: 45.75
+	Sc
		605841 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		GOSR1_YEAST (36-246): 6.41e-56: 180: 24.06
+	Dm
		1364307 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		GOSR1_DROME (5-250): 8.4e-72: 221: 45.75
+	Sc
		731037 YKT6_YEAST (31-188): 1.64e-44: 148: 24.54		GOSR1_YEAST (36-246): 6.41e-56: 180: 24.06